"I told you, don't call me Miss Kitty." Harry Goldman, young genius, DNA researcher and still a nerd, is back, and this time he's working for the law. At the end of Catnip, his girlfriend, Anastasia, devolved into a cat. He manages to bring her back to her half-human form, but no sooner does he do so than a new problem surfaces. Two other transgenics emerge, and they are out for blood. Harry and Anastasia have to face off against Lyudmila, another cat-girl, and Piotr, a half-rhino, half-boar monstrosity that lives to kill. And if that isn't bad enough, the police, lynch mobs, and underground dwellers are after Harry and his girlfriend as well. With time running out, they embark on a treacherous journey to the Ukraine in order to solve the riddle of Anastasia's DNA, a journey that could also cost both of them their lives.